Aldolase C
Aldolase C, fructose-bisphosphate, also known as ALDOC, is an enzyme that, in humans, is encoded by the ALDOC gene.[1][2]
Function
This gene encodes a member of the class I fructose-bisphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose 1,6-bisphosphate and fructose-1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde 3-phosphate or glyceraldehyde, respectively.[1]
References
Further reading
- Buono P, Mancini FP, Izzo P, Salvatore F (1990). "Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene.". Eur. J. Biochem. 192 (3): 805–11. doi:10.1111/j.1432-1033.1990.tb19294.x. PMID 2209624.
- Rocchi M, Vitale E, Covone A, et al. (1989). "Assignment of human aldolase C gene to chromosome 17, region cen----q21.1.". Hum. Genet. 82 (3): 279–82. doi:10.1007/BF00291170. PMID 2731939.
- Rottmann WH, Deselms KR, Niclas J, et al. (1987). "The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones.". Biochimie 69 (2): 137–45. doi:10.1016/0300-9084(87)90246-X. PMID 3105602.
- Buono P, Paolella G, Mancini FP, et al. (1988). "The complete nucleotide sequence of the gene coding for the human aldolase C.". Nucleic Acids Res. 16 (10): 4733. doi:10.1093/nar/16.10.4733. PMC 336672. PMID 3267224. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=336672.
- Tolan DR, Niclas J, Bruce BD, Lebo RV (1987). "Evolutionary implications of the human aldolase-A, -B, -C, and -pseudogene chromosome locations.". Am. J. Hum. Genet. 41 (5): 907–24. PMC 1684339. PMID 3674018. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1684339.
- Penhoet E, Rajkumar T, Rutter WJ (1967). "Multiple forms of fructose diphosphate aldolase in mammalian tissues.". Proc. Natl. Acad. Sci. U.S.A. 56 (4): 1275–82. doi:10.1073/pnas.56.4.1275. PMC 220058. PMID 5230152. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=220058.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146.
- Kim JH, Lee S, Kim JH, et al. (2002). "Phospholipase D2 directly interacts with aldolase via Its PH domain.". Biochemistry 41 (10): 3414–21. doi:10.1021/bi015700a. PMID 11876650.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Arakaki TL, Pezza JA, Cronin MA, et al. (2005). "Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function.". Protein Sci. 13 (12): 3077–84. doi:10.1110/ps.04915904. PMC 2287316. PMID 15537755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2287316.
- Buono P, Barbieri O, Alfieri A, et al. (2005). "Diverse human aldolase C gene promoter regions are required to direct specific LacZ expression in the hippocampus and Purkinje cells of transgenic mice.". FEBS Lett. 578 (3): 337–44. doi:10.1016/j.febslet.2004.11.032. PMID 15589842.
- Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.". Mol. Cell 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.
|
PDB gallery
|
|
|
|
1xfb: Human Brain Fructose 1,6-(bis)phosphate Aldolase (C isozyme)
|
|
|
|